The three best-known incretin research compounds differ mainly in which receptors they engage.
- Semaglutide — GLP-1 receptor only.
- Tirzepatide — GLP-1 and GIP receptors.
- Retatrutide — GLP-1, GIP and glucagon receptors.
Handling
All three are fatty-acid acylated, so they elute late on C18 and adsorb to surfaces in dilute solution. Swirl, never vortex.
Research use only. This article is educational and describes laboratory research. Nothing here is medical advice.